Myelin Repair Breakthrough : A study by Dr. Hyun Kyoung Lee at Baylor College of Medicine found a way to repair and grow back myelin, the protective coating on nerve impulses. Multiple sclerosis and other myelin-affecting diseases are untreatable, but this discovery offers new treatment possibilities.
The study found that Daam2 protein phosphorylation is crucial for oligodendrocyte development at various stages. Oligodendrocytes make myelin in the brain. The enzyme CK2 phosphorylates. CK2 and Daam2 protect newborns from brain damage from oxygen deprivation during birth. It also fixed myelin damage in older animals’ brains.
Myelin, compared to electrical insulation, is necessary for fast and efficient nerve impulse transmission over long distances. It’s mainly in the brain’s white matter but also body nerves. Demyelinating diseases, like multiple sclerosis, cause the protective sheath to break down, leading to nerve problems.
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Damage or loss of the myelin sheath is a sign of untreatable diseases. Multiple sclerosis is well-known, but myelin loss can result from other diseases, such as specific brain injuries.
The team studied the biochemistry and genes of phosphorylated Daam2 mice. “Daam2 phosphorylation impacts oligodendrocyte development stages differently,” Dr. Lee explained. In the early stages, it accelerates precursor cell transformation into glial cells. In later stages, it hampers their development and myelin production.
The find enables more study. Rebuilding lost myelin is a long-standing goal of medical science. Dr. Lee’s final comment highlights new ways to treat myelin damage and potentially alleviate untreatable neurological diseases.
The study’s results are important. New ways to aid those with myelin-degenerating diseases could be discovered by studying myelin restoration.
By studying kinase CK2’s impact on Daam2 phosphorylation, researchers have set the stage for potential drug treatments targeting these specific targets. Scientists hope to confirm early results and develop revolutionary treatments for long-standing diseases.
This study is a significant advancement in neurological research, as demyelinating diseases are common and lack effective treatments.
Our Reader’s Queries
Is myelin repair possible?
Contrary to popular belief, the brain is capable of repairing itself through myelin regeneration. This process has been observed in cases of injury or multiple sclerosis (MS), where spontaneous remyelination can occur. This evidence challenges the notion that brain repair is impossible and highlights the potential for further research and development in this area.
Can the body repair the myelin sheath?
The human body possesses a remarkable innate capability to restore myelin and restore proper nerve function. The repair or replacement of myelin is carried out by specialized cells in the brain known as oligodendrocytes. These cells are derived from a specific type of stem cell found in the brain, referred to as oligodendrocyte precursor cells (OPCs).
What is the new MS cure 2023?
Tyruko® (natalizumab-sztn) has made history as the first biosimilar to be approved by the FDA for the long-term treatment of MS. This groundbreaking approval was granted in August 2023, marking a significant milestone in the field of medicine. With this new medication, patients suffering from MS can now benefit from a safe and effective treatment option that has been rigorously tested and approved by the FDA. Tyruko® represents a major step forward in the fight against MS, and is sure to make a positive impact on the lives of countless patients.
Is there a way to regenerate myelin?
Boosting myelin production and regeneration can be achieved by incorporating various B vitamins into your diet. Among these vitamins, Vitamin B12 is particularly crucial in the generation and maintenance of myelin. Studies have shown that low levels of Vitamin B12 are linked to myelin degeneration, highlighting the importance of this vitamin in keeping your nervous system healthy.