Semaglutide Surge Dosing Errors and the Risky Game of Weight Loss

Semaglutide Surge Dosing Errors: Poison control centers in the US are grappling with a sharp surge in calls related to semaglutide, an injectable medication for diabetes and weight loss. America’s Poison Centers reported nearly 3,000 calls involving semaglutide from January to November, a staggering 15-fold increase since 2019. Most cases result from dosing errors, where patients unintentionally take the wrong or double dose.

Semaglutide, available as Ozempic for diabetes and Wegovy for weight loss, gained FDA approval in 2017. High demand caused shortages, leading some individuals to resort to compounded versions. However, these compounded forms may differ from the patented drug, resulting in dosing mistakes.

Compounded semaglutide is often dispensed in multidose vials, heightening the risk of confusion. Poison control centers are fielding calls predominantly from adults aged 40 to 70, citing symptoms such as severe nausea, vomiting, and stomach pain. Despite no specific antidote for semaglutide overdose, emergency departments can provide vital support with intravenous fluids and anti-nausea drugs.

Experts stress the crucial importance of proper usage and caution against opting for compounded versions. Individuals displaying symptoms of overdose are strongly urged to contact poison control centers promptly or seek immediate medical attention.

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Our Reader’s Queries

What is the dark side of semaglutide?

Although the safety of semaglutide in the long term is yet to be determined, it is important to note that the medication may pose a risk to individuals with heart or kidney issues. This includes the possibility of heart attack or stroke, as well as kidney failure or reduced kidney function. It is crucial to consult with a healthcare professional before taking this medication to ensure that it is safe for you.

Can I take more than 2.4 semaglutide?

For individuals aged 12 and above, the initial dosage involves injecting 0.25 milligrams (mg) under the skin once a week for a period of 4 weeks. Your physician may gradually increase your dosage every 4 weeks, but typically not exceeding 2.4 mg once a week.

Why is my semaglutide not working?

The effectiveness of medication can be reduced by various health issues such as kidney problems, liver issues, and psychological concerns. Patients with complex metabolic profiles often experience less weight loss with semaglutide compared to those with minimal health issues.

When does semaglutide peak?

When semaglutide is injected subcutaneously, its bioavailability is 89%. After injection, peak concentrations are reached in 3 days, and steady state is achieved by Week 5 when injected once weekly.

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